2010 Men's Lacrosse Schedule
| Overall | Pct. | Conf. | Pct. | Streak | Home | Away | Neutral |
| 19-2 | .905 | 6-1 | .857 | Lost 1 | 10-1 | 6-1 | 3-0 |
| Date | Opponent | Notes | Result | Time/Status | Links |
| Feb. 21 | vs. Widener @ Eastern | W, 15-3 | Final | Box Score Recap | |
| Feb. 27 | vs. Kean @ Towson | W, 24-4 | Final | Box Score Recap | |
| Mar. 3 | RIT | W, 20-10 | Final | Box Score Recap | |
| Mar. 7 | Western New England | W, 11-5 | Final | Box Score Recap | |
| Mar. 13 | vs. Lycoming @ Towson | W, 18-7 | Final | Box Score Recap | |
| Mar. 17 | Stevens | W, 16-11 | Final | Box Score Recap | |
| Mar. 20 | at Lynchburg | W, 12-9 | Final | Box Score Recap | |
| Mar. 24 | at Mary Washington * | W, 11-4 | Final | Box Score Recap | |
| Mar. 27 | Roanoke | W, 18-9 | Final | Box Score Recap | |
| Mar. 31 | at Hood * | W, 20-4 | Final | Box Score Recap | |
| Apr. 3 | Salisbury * | L, 16-10 | Final | Box Score Recap | |
| Apr. 7 | at Marymount (Va.) * | W, 18-6 | Final | Box Score Recap | |
| Apr. 10 | at Wesley * | W, 23-7 | Final | Box Score Recap | |
| Apr. 13 | St. Mary's (Md.) * | W, 13-10 | Final | Box Score Recap | |
| Apr. 15 | York (Pa.) * | W, 24-6 | Final | Box Score Recap | |
| Apr. 21 | St. Mary's (Md.) | CAC Semifinals | W, 16-3 | Final | Box Score Recap |
| Apr. 24 | at Salisbury | CAC Championship | W, 10-6 | Final | Box Score Recap |
| May. 1 | Denison | W, 13-9 | Final | Box Score Recap | |
| May. 15 | Cabrini | NCAA Second Round | W, 19-9 | Final | Box Score Recap |
| May. 19 | Roanoke | NCAA Quarterfinals | W, 15-14 | Final - OT | Box Score Recap |
| May. 23 | at Salisbury | NCAA Semifinals | L, 14-13 | Final - OT | Box Score Recap |
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* = Conference Game All times Eastern Home events shaded |
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